ACP-105

CAS No. 899821-23-9

ACP-105( —— )

Catalog No. M26597 CAS No. 899821-23-9

ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 57 In Stock
5MG 87 In Stock
10MG 160 In Stock
25MG 327 In Stock
50MG 507 In Stock
100MG 707 In Stock
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Biological Information

  • Product Name
    ACP-105
  • Note
    Research use only, not for human use.
  • Brief Description
    ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.
  • Description
    ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.(In Vitro):ACP-105 is an SARM with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively. The half-lives of ACP-105 in human hepatocytes is 5.0 h.(In Vivo):Irradiation impaired sensorimotor function in vehicle-treated mice but not in ACP-105-treated mice. Irradiation impaired cued fear conditioning and ACP-105 enhanced fear conditioning in sham-irradiated and irradiated mice. There are relatively early radiation-induced behavioral changes in female mice and reduced MAP-2 levels in the sensorimotor cortex following ACP-105 treatment might contribute to enhanced rotorod performance.
  • In Vitro
    ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively. The half-lives of ACP-105 (compound 1) in human hepatocytes is measured and found to be 5.0 h.
  • In Vivo
    ACP-105 enhances freezing in both sham-irradiated and irradiated mice (effect of ACP-105: F=5.44; p=0.028). For MAP-2 immunoreactivity in the cortex of sham-irradiated mice, there is a brain area×ACP-105 interaction (F=6.655; p=0.0027). While ACP-105 reduces MAP-2 immunoreactivity in the sensorymotor cortex, there is a trend towards increased MAP-2 immunoreactivity in the enthorhinal cortex.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Androgen Receptor (AR)
  • Recptor
    HIV| Influenza virus| α1,2-mannosidase I
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    899821-23-9
  • Formula Weight
    290.79
  • Molecular Formula
    C16H19ClN2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 103 mg/mL (354.21 mM)
  • SMILES
    Cc1c(Cl)c(ccc1N1[C@H]2CC[C@@H]1C[C@](C)(O)C2)C#N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jan Balzarini, et al. The alpha(1,2)-mannosidase I Inhibitor 1-deoxymannojirimycin Potentiates the Antiviral Activity of Carbohydrate-Binding Agents Against Wild-Type and Mutant HIV-1 Strains Containing Glycan Deletions in gp120. FEBS Lett. 2007 May 15;581(10):2060-4.
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