ACP-105

Research use only, not for human use.

ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.

ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.(In Vitro):ACP-105 is an SARM with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively. The half-lives of ACP-105 in human hepatocytes is 5.0 h.(In Vivo):Irradiation impaired sensorimotor function in vehicle-treated mice but not in ACP-105-treated mice. Irradiation impaired cued fear conditioning and ACP-105 enhanced fear conditioning in sham-irradiated and irradiated mice. There are relatively early radiation-induced behavioral changes in female mice and reduced MAP-2 levels in the sensorimotor cortex following ACP-105 treatment might contribute to enhanced rotorod performance.

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Endocrinology/Hormones

Androgen Receptor (AR)

HIV; Influenza virus; α1,2-mannosidase I

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899821-23-9

290.8

C16H19ClN2O

>98% (HPLC)

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Cc1c(Cl)c(ccc1N1[C@H]2CC[C@@H]1C[C@](C)(O)C2)C#N

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(-20℃)

With Ice Pack

≥ 2 years