AC1NS4RE( SU5614 | SU 5614 | SU5614 )

Catalog No. M17129 CAS No. 1055412-47-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

AC1NS4RE
Note

Research use only, not for human use.
Brief Description

SU5614 is a potent and selective FLT3 inhibitor. SU5614 has inhibitory activity for FLT3 and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3.
Description

SU5614 is a potent and selective FLT3 inhibitor. SU5614 has inhibitory activity for FLT3 and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3. SU5614 reverts the antiapoptotic and pro-proliferative activity of FLT3 ligand (FL) in FL-dependent cells. SU5614 down-regulated the activity of the hyperphosphorylated FLT3 receptor and its downstream targets, signal transducer and activator of (STAT) 3, STAT5, and mitogen-activated protein kinase (MAPK), and the STAT5 target genes BCL-X(L) and p21.
In Vitro

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In Vivo

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Synonyms

SU5614 | SU 5614 | SU5614
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Cancer
Indication

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CAS Number

1055412-47-9
Formula Weight

272.73
Molecular Formula

C15H13ClN2O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 16.67 mg/mL (61.12 mM)
SMILES

Cc1cc(c([nH]1)/C=C\1/c2c(ccc(c2)Cl)NC1=O)C
Chemical Name

(3Z)-5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one