AC-264613 ( AC-264613; AC 264613; AC264613 )

Catalog No. M17128 CAS No. 1051487-82-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

AC-264613
Note

Research use only, not for human use.
Brief Description

AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2).
Description

AC-264613 is the first agonist of the G-protein-coupled receptor (GPCR) protease activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages. AC-264613 activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 30 to 100 nM.
Synonyms

AC-264613; AC 264613; AC264613
Pathway

Others
Target

Other Targets
Recptor

PAR-2
Research Area

——
Indication

——

CAS Number

1051487-82-1
Formula Weight

400.28
Molecular Formula

C19H18BrN3O2
Purity

98%
Solubility

——
SMILES

O=C([C@H]1C(=O)NC[C@@H]1c1ccccc1)N/N=C(/c1cccc(Br)c1)\C
Chemical Name

(3R,4S)-rel-2-Oxo-4-phenyl-3-pyrrolidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide

1.Cosimi E, et al. Stereoselective Synthesis of α-Fluoro-γ-nitro Thioesters under Organocatalytic Conditions. Org Lett. 2016 Dec 2;18(23):6014-6017

Calculator

molnova catalog