AC-264613( AC-264613 | AC 264613 | AC264613 )

Catalog No. M17128 CAS No. 1051487-82-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

AC-264613
Note

Research use only, not for human use.
Brief Description

AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2).
Description

AC-264613 is the first agonist of the G-protein-coupled receptor (GPCR) protease activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages. AC-264613 activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 30 to 100 nM.
In Vitro

AC-264613 (10 μM; for 6 hours) causes a decrease of IRF5 expression and also significantly reduces p53 protein expression in macrophages. Western Blot Analysis Cell Line:Granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent macrophages Concentration:10 μM Incubation Time:6 hours Result:Significantly decreased IRF5 expression and reduced p53 protein levels.
In Vivo

AC-264613 exhibits moderate elimination half-live (T1/2=2.5±2.0 h) following i.p. administration (10 mg/kg) in male Sprague-Dawley rats.
Synonyms

AC-264613 | AC 264613 | AC264613
Pathway

Others
Target

Other Targets
Recptor

PAR-2
Research Area

——
Indication

——

CAS Number

1051487-82-1
Formula Weight

400.28
Molecular Formula

C19H18BrN3O2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C([C@H]1C(=O)NC[C@@H]1c1ccccc1)N/N=C(/c1cccc(Br)c1)\C
Chemical Name

(3R,?4S)?-?rel-2-?Oxo-?4-?phenyl-?3-?pyrrolidinecarboxyli?c acid 2-?[1-?(3-?bromophenyl)?ethylidene]?hydrazide

1.Cosimi E, et al. Stereoselective Synthesis of α-Fluoro-γ-nitro Thioesters under Organocatalytic Conditions. Org Lett. 2016 Dec 2;18(23):6014-6017

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