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ABT-724

CAS No. 70006-24-5

ABT-724( —— )

Catalog No. M21091 CAS No. 70006-24-5

ABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ABT-724
  • Note
    Research use only, not for human use.
  • Brief Description
    ABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM).
  • Description
    ABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM).
  • In Vitro
    ABT-724 exhibits a selective biochemical profile, as indicates by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors up to a 10 μM concentration. A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT-724 does not inhibit the PDE activity of PDE1, PDE5, or PDE6 at 10 μM concentrations.
  • In Vivo
    ABT-724 (8.8 μg/kg; subcutaneous injection; daily; for 5 days; male adult Wistar rats) treatment dose-dependently facilitates penile erection when given s.c. to conscious rats. Animal Model:Male adult Wistar rats (~300 g) Dosage:8.8 μg/kg Administration:Subcutaneous injection; daily; for 5 daysResult:Dose-dependently facilitated penile erection.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    D4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    70006-24-5
  • Formula Weight
    293.37
  • Molecular Formula
    C17H19N5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1
  • Chemical Name
    1H-Benzimidazole 2-((4-(2-pyridinyl)-1-piperazinyl)methyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Brioni J D Moreland R B Cowart M et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats[J]. Proceedings of the National Academy of Sciences 2004 101(17):6758-6763.
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