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ABT-239

CAS No. 460746-46-7

ABT-239 ( ABT239;ABT 239 )

Catalog No. M14550 CAS No. 460746-46-7

A potent and selective Histamine H3 receptor antagonist with Ki of 0.1-5.8 nM (human, rat H3).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ABT-239
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective Histamine H3 receptor antagonist with Ki of 0.1-5.8 nM (human, rat H3).
  • Description
    A potent and selective Histamine H3 receptor antagonist with Ki of 0.1-5.8 nM (human, rat H3); exhibits 1000-fold selectivity versus H1, H2 and H4; excellent pharmacokinetic and metabolic properties across species and good oral bioavailability.Pain Discontinued
  • Synonyms
    ABT239;ABT 239
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    Histamine Receptor
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    460746-46-7
  • Formula Weight
    330.42
  • Molecular Formula
    C22H22N2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 3.3 mg/mL
  • SMILES
    N#CC1=CC=C(C2=CC=C(OC(CCN3[C@H](C)CCC3)=C4)C4=C2)C=C1
  • Chemical Name
    Benzonitrile, 4-[2-[2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl]-5-benzofuranyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cowart M, et al. J Med Chem. 2005 Jan 13;48(1):38-55.
2. Esbenshade TA, et al. J Pharmacol Exp Ther. 2005 Apr;313(1):165-75.
3. Bhowmik M, et al. Brain Res. 2014 Sep 18;1581:129-40.
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