ABT-239 ( ABT239;ABT 239 )

Catalog No. M14550 CAS No. 460746-46-7

A potent and selective Histamine H3 receptor antagonist with Ki of 0.1-5.8 nM (human, rat H3).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
5MG	87	Get Quote
10MG	155	Get Quote
25MG	335	Get Quote
50MG	500	Get Quote
100MG	705	Get Quote
500MG	1485	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

ABT-239
Note

Research use only, not for human use.
Brief Description

A potent and selective Histamine H3 receptor antagonist with Ki of 0.1-5.8 nM (human, rat H3).
Description

A potent and selective Histamine H3 receptor antagonist with Ki of 0.1-5.8 nM (human, rat H3); exhibits 1000-fold selectivity versus H1, H2 and H4; excellent pharmacokinetic and metabolic properties across species and good oral bioavailability.Pain Discontinued
Synonyms

ABT239;ABT 239
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

Histamine Receptor
Research Area

Neurological Disease
Indication

Pain

Chemical Information

CAS Number

460746-46-7
Formula Weight

330.42
Molecular Formula

C22H22N2O
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 3.3 mg/mL
SMILES

N#CC1=CC=C(C2=CC=C(OC(CCN3[C@H](C)CCC3)=C4)C4=C2)C=C1
Chemical Name

Benzonitrile, 4-[2-[2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl]-5-benzofuranyl]-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Cowart M, et al. J Med Chem. 2005 Jan 13;48(1):38-55.
2. Esbenshade TA, et al. J Pharmacol Exp Ther. 2005 Apr;313(1):165-75.
3. Bhowmik M, et al. Brain Res. 2014 Sep 18;1581:129-40.

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