AAI-101 ( AAI 101;AAI101 )

Catalog No. M10015 CAS No. 1001404-83-6

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Product Name

AAI-101
Note

Research use only, not for human use.
Brief Description

AAI-101 is a novel extended-spectrum β-lactamase inhibitor with activity against many β-lactamases, including some class A and class D carbapenemases.
Description

AAI-101 is a novel extended-spectrum β-lactamase inhibitor with activity against many β-lactamases, including some class A and class D carbapenemases; is currently in clinical development as a combination with cefepime, reduces the MIC50 of cefepime against a collection of 223 cefepime-nonsusceptible isolates of the family Enterobacteriaceae from >64 mg/L to 0.125 mg/L.Bacterial Infection Phase 1 Clinical
Synonyms

AAI 101;AAI101
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

Infection
Indication

Bacterial Infection

CAS Number

1001404-83-6
Formula Weight

314.32
Molecular Formula

C11H14N4O5S
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 113.3 mg/mL 360.46 mM
SMILES

C[N+]1=NN(C[C@@](S([C@]2([H])C3)(=O)=O)(C)[C@H](C([O-])=O)N2C3=O)C=C1
Chemical Name

(2S,3S,5R)-3-methyl-3-((1-methyl-1H-1,2,3-triazol-3-ium-3-yl)methyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide

1. Crandon JL, et al. Antimicrob Agents Chemother. 2015 May;59(5):2688-94.
2. Crandon JL, et al. Pathogens. 2015 Aug 18;4(3):620-5.

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