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A-674563
CAS No. 552325-73-2
A-674563 ( A 674563;A674563 )
Catalog No. M15000 CAS No. 552325-73-2
A-674563 is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 187 | In Stock |
|
| 5MG | 124 | In Stock |
|
| 10MG | 493 | In Stock |
|
| 25MG | 935 | In Stock |
|
| 50MG | 1492 | In Stock |
|
| 100MG | 2518 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameA-674563
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NoteResearch use only, not for human use.
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Brief DescriptionA-674563 is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1).
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DescriptionA-674563 is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1); increases the efficacy of paclitaxel in a PC-3 xenograft model; enhances the transcription of several chondrocyte marker genes, including Col2a1, Acan and Col11a2, in mouse primary chondrocytes by inhibiting Sox9 degradation through the ubiquitin-proteasome pathway; also suppresses FLT3-ITD positive AML both in vitro and in vivo.
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SynonymsA 674563;A674563
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt1;CDK2;ERK2;GSK-3β;PKA
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number552325-73-2
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Formula Weight358.40
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Molecular FormulaC22H22N4O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESN[C@@H](CC1=CC=CC=C1)COC2=CC(C3=CC4=C(NN=C4C)C=C3)=CN=C2
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Chemical NameBenzeneethanamine, a-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (aS)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Luo Y, et al. Mol Cancer Ther. 2005 Jun;4(6):977-86.
2. Tei H, et al. Hum Cell. 2015 Jul;28(3):114-21.
3. Wang A, et al. Oncotarget. 2016 May 17;7(20):29131-42.
4. Kobayashi T, et al. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1468-1475.
2. Tei H, et al. Hum Cell. 2015 Jul;28(3):114-21.
3. Wang A, et al. Oncotarget. 2016 May 17;7(20):29131-42.
4. Kobayashi T, et al. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1468-1475.
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