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Home - Products - Cytoskeleton/Cell Adhesion Molecules - Akt - A-443654

A-443654

CAS No. 552325-16-3

A-443654 ( A 443654;A443654 )

Catalog No. M14999 CAS No. 552325-16-3

A potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 692 Get Quote
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Biological Information

  • Product Name
    A-443654
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1.
  • Description
    A potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1; has equal potency against Akt1, Akt2, or Akt3 within cells, displays 40-fold selectivity over PKA, and CMGC family kinases; inhibits Akt-dependent signal transduction, inhibits proliferation of MiaPaCa-2 cells with EC50 of 0.1 uM; inhibits tumor growth in vivo, and is more potent and more selective than A-674563.
  • Synonyms
    A 443654;A443654
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    Akt
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    552325-16-3
  • Formula Weight
    397.47
  • Molecular Formula
    C24H23N5O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    N[C@H](COC1=CC(C2=CC3=C(C)NN=C3C=C2)=CN=C1)CC4=CNC5=C4C=CC=C5
  • Chemical Name
    1H-Indole-3-ethanamine, .alpha.-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (.alpha.S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Luo Y, et al. Mol Cancer Ther. 2005 Jun;4(6):977-86.
2. Han EK, et al. Oncogene. 2007 Aug 16;26(38):5655-61.
3. Shi Y, et al. Neoplasia. 2005 Nov;7(11):992-1000.
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