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A-443654
CAS No. 552325-16-3
A-443654 ( A 443654;A443654 )
Catalog No. M14999 CAS No. 552325-16-3
A potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 245 | Get Quote |
|
| 10MG | 416 | Get Quote |
|
| 25MG | 692 | Get Quote |
|
| 50MG | 954 | Get Quote |
|
| 100MG | 1287 | Get Quote |
|
| 200MG | 1737 | Get Quote |
|
| 500MG | 2592 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameA-443654
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1.
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DescriptionA potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1; has equal potency against Akt1, Akt2, or Akt3 within cells, displays 40-fold selectivity over PKA, and CMGC family kinases; inhibits Akt-dependent signal transduction, inhibits proliferation of MiaPaCa-2 cells with EC50 of 0.1 uM; inhibits tumor growth in vivo, and is more potent and more selective than A-674563.
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SynonymsA 443654;A443654
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number552325-16-3
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Formula Weight397.47
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Molecular FormulaC24H23N5O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESN[C@H](COC1=CC(C2=CC3=C(C)NN=C3C=C2)=CN=C1)CC4=CNC5=C4C=CC=C5
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Chemical Name1H-Indole-3-ethanamine, .alpha.-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (.alpha.S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Luo Y, et al. Mol Cancer Ther. 2005 Jun;4(6):977-86.
2. Han EK, et al. Oncogene. 2007 Aug 16;26(38):5655-61.
3. Shi Y, et al. Neoplasia. 2005 Nov;7(11):992-1000.
2. Han EK, et al. Oncogene. 2007 Aug 16;26(38):5655-61.
3. Shi Y, et al. Neoplasia. 2005 Nov;7(11):992-1000.
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