A-443654

CAS No. 552325-16-3

A-443654( A 443654;A443654 )

Catalog No. M14999 CAS No. 552325-16-3

A potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 245 Get Quote
10MG 416 Get Quote
25MG 692 Get Quote
50MG 954 Get Quote
100MG 1287 Get Quote
200MG 1737 Get Quote
500MG 2592 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    A-443654
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1.
  • Description
    A potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1; has equal potency against Akt1, Akt2, or Akt3 within cells, displays 40-fold selectivity over PKA, and CMGC family kinases; inhibits Akt-dependent signal transduction, inhibits proliferation of MiaPaCa-2 cells with EC50 of 0.1 uM; inhibits tumor growth in vivo, and is more potent and more selective than A-674563.
  • Synonyms
    A 443654;A443654
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    Akt
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    552325-16-3
  • Formula Weight
    397.47
  • Molecular Formula
    C24H23N5O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    N[C@H](COC1=CC(C2=CC3=C(C)NN=C3C=C2)=CN=C1)CC4=CNC5=C4C=CC=C5
  • Chemical Name
    1H-Indole-3-ethanamine, .alpha.-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (.alpha.S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Luo Y, et al. Mol Cancer Ther. 2005 Jun;4(6):977-86.
2. Han EK, et al. Oncogene. 2007 Aug 16;26(38):5655-61.
3. Shi Y, et al. Neoplasia. 2005 Nov;7(11):992-1000.
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