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A-1048400
CAS No. 1219624-62-0
A-1048400( A1048400 )
Catalog No. M10826 CAS No. 1219624-62-0
A novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameA-1048400
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively.
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DescriptionA novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively; shows no significant activity against L-type Ca2+ channels (IC50=28 uM); reverses tactile allodynia in model of capsaicin-induced secondary hypersensitivity (EC50=300-365 ng/ml), without effect on hemodynamic function; blocks native N- and T-type Ca2+ currents in rat dorsal root ganglion neurons (IC50=3.0 and 1.6 uM), attenuates nociceptive, neuropathic and inflammatory pain in vivo.Pain Discontinued.
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In Vitro——
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In Vivo——
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SynonymsA1048400
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCalcium Channel
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number1219624-62-0
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Formula Weight543.711
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Molecular FormulaC36H37N3O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C1N(CC(N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)=O)CCCC1(C5=CC=CC=C5)C6=CC=CC=C6
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Chemical Name1-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl)-3,3-diphenylpiperidin-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Scott VE, et al. Biochem Pharmacol. 2012 Feb 1;83(3):406-18.
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