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7-Hydroxymethotrexate
CAS No. 5939-37-7
7-Hydroxymethotrexate( —— )
Catalog No. M33666 CAS No. 5939-37-7
7-Hydroxymethotrexate is the major metabolite of Methotrexate.Methotrexate is an inhibitor of folic acid, inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, and inhibiting DNA synthesis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 474 | Get Quote |
|
| 5MG | 712 | Get Quote |
|
| 10MG | 938 | Get Quote |
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| 25MG | 1408 | Get Quote |
|
| 50MG | 2254 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product Name7-Hydroxymethotrexate
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NoteResearch use only, not for human use.
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Brief Description7-Hydroxymethotrexate is the major metabolite of Methotrexate.Methotrexate is an inhibitor of folic acid, inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, and inhibiting DNA synthesis.
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Description7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
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In Vitro7-Hydroxymethotrexate (7-OHMTX) has the affinity of DHFR markedly lower (>100-fold) than for Methotrexate (MTX) .
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In Vivo7-Hydroxymethotrexate (4 mg/kg; IV) has a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min?mg.Animal Model:Male Wistar rats (270-440 g)Dosage:4 mg/kg (Pharmacokinetic Analysis)Administration:IVResult:Had a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min?mg.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorDrug Metabolite
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Research Area——
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Indication——
Chemical Information
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CAS Number5939-37-7
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Formula Weight470.44
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Molecular FormulaC20H22N8O6
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Purity>98% (HPLC)
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Solubility——
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SMILESNC1=C2C(NC(=O)C(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=NC(N)=N1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. L Fahrig, et al. Pharmacokinetics of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) in rats and evidence for the metabolism of MTX to 7-OH-MTX. Cancer Chemother Pharmacol. 1989;23(3):156-60.?
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