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Home - Products - Proteasome/Ubiquitin - Endogenous Metabolite - 7-Dehydrocholesterol

7-Dehydrocholesterol

CAS No. 434-16-2

7-Dehydrocholesterol( 7-DHC | Provitamin D3 )

Catalog No. M19772 CAS No. 434-16-2

7-Dehydrocholesterol down-regulates cholesterol biosynthesis in cultured Smith-Lemi-Opitz syndrome skin fibroblasts.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    7-Dehydrocholesterol
  • Note
    Research use only, not for human use.
  • Brief Description
    7-Dehydrocholesterol down-regulates cholesterol biosynthesis in cultured Smith-Lemi-Opitz syndrome skin fibroblasts.
  • Description
    7-Dehydrocholesterol down-regulates cholesterol biosynthesis in cultured Smith-Lemi-Opitz syndrome skin fibroblasts.(In Vitro):7-Dehydrocholesterol is a biosynthetic precursor of cholesterol and vitamin D3. 7-Dehydrocholesterol is present in relatively high concentration in skin where it is converted to pre-vitamin D3 upon UV irradiation and where it is also exposed to exogenous radical sources and oxygen.
  • In Vitro
    7-Dehydrocholesterol is a biosynthetic precursor of cholesterol and vitamin D3. 7-Dehydrocholesterol is present in relatively high concentration in skin where it is converted to pre-vitamin D3 upon UV irradiation and where it is also exposed to exogenous radical sources and oxygen.
  • In Vivo
    ——
  • Synonyms
    7-DHC | Provitamin D3
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    Human Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    434-16-2
  • Formula Weight
    384.64
  • Molecular Formula
    C27H44O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10mM
  • SMILES
    CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lehmann B Genehr T Knuschke P et al. UVB-Induced Conversion of 7-Dehydrocholesterol to 1α25-Dihydroxyvitamin D3 in an In Vitro Human Skin Equivalent Model[J]. Journal of Investigative Dermatology 2001 117(5):1179.
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