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6RK73

CAS No. 1895050-66-4

6RK73 ( —— )

Catalog No. M26038 CAS No. 1895050-66-4

6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 μM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
5MG	282	Get Quote
10MG	483	Get Quote
25MG	782	Get Quote
50MG	1071	Get Quote
100MG	1431	Get Quote
500MG	2898	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

6RK73
Note

Research use only, not for human use.
Brief Description

6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 μM).
Description

6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 μM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 μM).(In Vitro):6RK73 (5 μM; 1-3 hours) treatment displays strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels in MDA-MB-436 cells. 6RK73 (5 μM; 24-48 hours) results in migration significantly slower than the DMSO control group in MDA-MB-436 cells.(In Vivo):6RK73 displays a potent inhibition of breast cancer extravasation in zebrafish.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Antioxidant
Research Area

——
Indication

——

Chemical Information

CAS Number

1895050-66-4
Formula Weight

307.4
Molecular Formula

C13H17N5O2S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(Nc1ncc(s1)N1CCOCC1)[C@H]1CCN(C1)C#N
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Safranal Attenuates Excitotoxin-Induced Oxidative OLN-93 Cells Injury

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