6-Methoxydihydrosanguinarine
CAS No. 72401-54-8
6-Methoxydihydrosanguinarine ( —— )
Catalog No. M22599 CAS No. 72401-54-8
6-Methoxydihydrosanguinarine is a natural product.?6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 332 | In Stock |
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10MG | 488 | In Stock |
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25MG | 776 | In Stock |
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50MG | 1044 | In Stock |
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100MG | 1404 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product Name6-Methoxydihydrosanguinarine
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NoteResearch use only, not for human use.
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Brief Description6-Methoxydihydrosanguinarine is a natural product.?6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.
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Description6-Methoxydihydrosanguinarine is a natural product.?6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.It has antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentrations (MICs) ranging from1.9 to 3.9 microg/ml6-methoxydihydrosanguinarine (6ME), a benzophenanthridine alkaloid isolated from Hylomecon species, may have potential as a chemotherapeutic agent.??6ME inhibits the growth of HepG2 cells in a concentration- and time-dependent manner (IC50=3.8+/-0.2 microM following 6 h incubation).?Treatment of HepG2 cells with 6ME resulted in the release of mitochondrial cytochrome c followed by the activation of caspase proteases, and subsequent proteolytic cleavage of poly(ADP-ribose) polymerase.?6ME increased the expression of p53 and bax and decreased the expression of bcl-2.?The cytotoxic effect of 6ME is mediated by the time-dependent generation of reactive oxygen species.?Preincubation of HepG2 cells with vitamin C decreased the expression of p53 and bax and inhibited the release of cytochrome c, activation of downstream caspase and the cleavage of poly(ADP-ribose) polymerase, thus inhibiting the apoptosis inducing effect of 6ME.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number72401-54-8
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Formula Weight363.36
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Molecular FormulaC21H17NO5
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Purity>98% (HPLC)
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Solubility——
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SMILESCOC1N(C)c2c(ccc3cc4OCOc4cc23)-c2ccc3OCOc3c12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yin H Q , Kim Y H , Moon C K , et al. Reactive oxygen species-mediated induction of apoptosis by a plant alkaloid 6-methoxydihydrosanguinarine in HepG2 cells[J]. Biochemical Pharmacology, 2005, 70(2):242-248.
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