6-Methoxydihydrosanguinarine

CAS No. 72401-54-8

6-Methoxydihydrosanguinarine ( —— )

Catalog No. M22599 CAS No. 72401-54-8

6-Methoxydihydrosanguinarine is a natural product.?6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    6-Methoxydihydrosanguinarine
  • Note
    Research use only, not for human use.
  • Brief Description
    6-Methoxydihydrosanguinarine is a natural product.?6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.
  • Description
    6-Methoxydihydrosanguinarine is a natural product.?6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.It has antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentrations (MICs) ranging from1.9 to 3.9 microg/ml6-methoxydihydrosanguinarine (6ME), a benzophenanthridine alkaloid isolated from Hylomecon species, may have potential as a chemotherapeutic agent.??6ME inhibits the growth of HepG2 cells in a concentration- and time-dependent manner (IC50=3.8+/-0.2 microM following 6 h incubation).?Treatment of HepG2 cells with 6ME resulted in the release of mitochondrial cytochrome c followed by the activation of caspase proteases, and subsequent proteolytic cleavage of poly(ADP-ribose) polymerase.?6ME increased the expression of p53 and bax and decreased the expression of bcl-2.?The cytotoxic effect of 6ME is mediated by the time-dependent generation of reactive oxygen species.?Preincubation of HepG2 cells with vitamin C decreased the expression of p53 and bax and inhibited the release of cytochrome c, activation of downstream caspase and the cleavage of poly(ADP-ribose) polymerase, thus inhibiting the apoptosis inducing effect of 6ME.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    72401-54-8
  • Formula Weight
    363.36
  • Molecular Formula
    C21H17NO5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COC1N(C)c2c(ccc3cc4OCOc4cc23)-c2ccc3OCOc3c12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yin H Q , Kim Y H , Moon C K , et al. Reactive oxygen species-mediated induction of apoptosis by a plant alkaloid 6-methoxydihydrosanguinarine in HepG2 cells[J]. Biochemical Pharmacology, 2005, 70(2):242-248.
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