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6-MOMIPP

CAS No. 1961272-45-6

6-MOMIPP( —— )

Catalog No. M13076 CAS No. 1961272-45-6

6-MOMIPP is a novel microtubule disruptor that targets the colchicine binding site on β-tubulin, induces mitotic arrest, caspase activation and loss of cell viability of U251 glioblastoma in vitro.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    6-MOMIPP
  • Note
    Research use only, not for human use.
  • Brief Description
    6-MOMIPP is a novel microtubule disruptor that targets the colchicine binding site on β-tubulin, induces mitotic arrest, caspase activation and loss of cell viability of U251 glioblastoma in vitro.
  • Description
    6-MOMIPP is a novel microtubule disruptor that targets the colchicine binding site on β-tubulin, induces mitotic arrest, caspase activation and loss of cell viability of U251 glioblastoma in vitro; demonstrates broad activity against the viability of multiple glioblastoma, melanoma and lung carcinoma cell lines; effectively inhibits growth of subcutaneous and intracerebral tumors without causing general toxicity in mice bearing human U251 glioblastoma xenografts.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Microtubule/Tubulin
  • Recptor
    Microtubule/Tubulin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1961272-45-6
  • Formula Weight
    292.338
  • Molecular Formula
    C18H16N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=C(C2=C(N1)C=C(C=C2)OC)C=CC(=O)C3=CC=NC=C3
  • Chemical Name
    3-(6-Methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propene-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Du S, et al. Cancer Chemother Pharmacol. 2018 Nov 13. doi: 10.1007/s00280-018-3726-1.
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