5-Methoxytryptophol

CAS No. 712-09-4

5-Methoxytryptophol ( Methoxytryptophol; 2-(5-Methoxy-1H-indol-3-yl)ethanol )

Catalog No. M26544 CAS No. 712-09-4

5-Methoxytryptophol is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 27 Get Quote
25MG 58 Get Quote
50MG 88 Get Quote
100MG 135 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    5-Methoxytryptophol
  • Note
    Research use only, not for human use.
  • Brief Description
    5-Methoxytryptophol is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.
  • Description
    5-Methoxytryptophol is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.(In Vitro):In MC3T3-E1 cells, most of the 5-methoxytryptophol doses reduced slightly the metabolic activity of osteoblasts. After 14 days of cell culture, Rankl mRNA levels were decreased. 5-methoxytryptophol also induced a high osteocalcin secretion and mineralization capacity. In RAW264.7 cells, 5-methoxytryptophol decreased the number of osteoclast formed and its activity. 5-methoxytryptophol promoted activation of the ERK1/2 pathway through the phosphorylation of ERK, while LUZ addition suppressed this effect. In conclusion, 5-methoxytryptophol inhibits osteoclastogenesis and promoting osteoblast differentiation.
  • Synonyms
    Methoxytryptophol; 2-(5-Methoxy-1H-indol-3-yl)ethanol
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    NSD2-PWWP1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    712-09-4
  • Formula Weight
    191.2
  • Molecular Formula
    C11H13NO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc1ccc2[nH]cc(CCO)c2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dilworth D, et al. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat Chem Biol. 2022 Jan;18(1):56-63.
molnova catalog
related products
  • Tricosanoic acid

    Tricosylic acid also known as N-tricosanoate or tricosylate belongs to the class of organic compounds known as very long-chain fatty acids.

  • Norgestimate metabol...

    Norelgestromin is one of the active metabolites of norgestimate.It is a steroidal progestin used in contraceptive patches, where it is combined with the estrogen ethinyl estradiol.

  • Cinnamic acid (b)

    Cinnamic acid has potential use in cancer interventionThe concentration causing a 50% reduction of cell proliferation (IC50) ranged from 1 to 4.5 mM in glioblastoma melanoma prostate and lung carcinoma cells.