5-Methoxytryptophol

CAS No. 712-09-4

5-Methoxytryptophol ( Methoxytryptophol; 2-(5-Methoxy-1H-indol-3-yl)ethanol )

Catalog No. M26544 CAS No. 712-09-4

5-Methoxytryptophol is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 27 Get Quote
25MG 58 Get Quote
50MG 88 Get Quote
100MG 135 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
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Biological Information

  • Product Name
    5-Methoxytryptophol
  • Note
    Research use only, not for human use.
  • Brief Description
    5-Methoxytryptophol is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.
  • Description
    5-Methoxytryptophol is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.(In Vitro):In MC3T3-E1 cells, most of the 5-methoxytryptophol doses reduced slightly the metabolic activity of osteoblasts. After 14 days of cell culture, Rankl mRNA levels were decreased. 5-methoxytryptophol also induced a high osteocalcin secretion and mineralization capacity. In RAW264.7 cells, 5-methoxytryptophol decreased the number of osteoclast formed and its activity. 5-methoxytryptophol promoted activation of the ERK1/2 pathway through the phosphorylation of ERK, while LUZ addition suppressed this effect. In conclusion, 5-methoxytryptophol inhibits osteoclastogenesis and promoting osteoblast differentiation.
  • Synonyms
    Methoxytryptophol; 2-(5-Methoxy-1H-indol-3-yl)ethanol
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    NSD2-PWWP1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    712-09-4
  • Formula Weight
    191.2
  • Molecular Formula
    C11H13NO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc1ccc2[nH]cc(CCO)c2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dilworth D, et al. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat Chem Biol. 2022 Jan;18(1):56-63.
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