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Home - Products - GPCR/G Protein - Bradykinin Receptor - 5-Hydroxy-1-methylhydantoin

5-Hydroxy-1-methylhydantoin

CAS No. 84210-26-4

5-Hydroxy-1-methylhydantoin( NZ-419 | HD-003 )

Catalog No. M27907 CAS No. 84210-26-4

NZ-419 is an antioxidant potentially for the treatment of renal failure.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    5-Hydroxy-1-methylhydantoin
  • Note
    Research use only, not for human use.
  • Brief Description
    NZ-419 is an antioxidant potentially for the treatment of renal failure.
  • Description
    NZ-419 is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, NZ-419, a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. NZ-419 a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. NZ-419 inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that NZ-419 may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NZ-419 | HD-003
  • Pathway
    GPCR/G Protein
  • Target
    Bradykinin Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    84210-26-4
  • Formula Weight
    114.1
  • Molecular Formula
    C4H6N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1NC(CN1C)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dana M, et al. Synthesis of homoveratric acid-imprinted polymers and their evaluation as selective separation materials. Molecules. 2011 May 5;16(5):3826-44.
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