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5(6)-Carboxyfluorescein

CAS No. 72088-94-9

5(6)-Carboxyfluorescein( 5(6)-FAM | 5-(and-6)-Carboxyfluorescein mixed isomers )

Catalog No. M24732 CAS No. 72088-94-9

5(6)-Carboxyfluorescein contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    5(6)-Carboxyfluorescein
  • Note
    Research use only, not for human use.
  • Brief Description
    5(6)-Carboxyfluorescein contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid.
  • Description
    5(6)-Carboxyfluorescein contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid.
  • In Vitro
    5(6)-Carboxyfluorescein has two main characteristics: it has two wavelengths of maximum absorbance (465 and 490 nm) and its fluorescence emission (maximum, 515 nm) increases as a function of pH in the physiological pH range of 6-7.4.
  • In Vivo
    5(6)-Carboxyfluorescein (5 mg/kg; i.p.) can be used for in vivo pH mapping of tumor tissue. Animal Model:CDF mice, bearing lymphoid leukemia P388 Dosage:5 mg/kg Administration:Injected intraperitoneally Result:Could be used for measurement and imaging of tumor tissue.
  • Synonyms
    5(6)-FAM | 5-(and-6)-Carboxyfluorescein mixed isomers
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    72088-94-9
  • Formula Weight
    376.32
  • Molecular Formula
    C21H12O7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:41 mg/mL (108.95 mM)
  • SMILES
    OC1=CC=C(C2(O3)C(C=C(C(O)=O)C=C4)=C4C3=O)C(OC5=C2C=CC(O)=C5)=C1.OC6=CC=C(C7(O8)C(C=CC(C(O)=O)=C9)=C9C8=O)C(OC%10=C7C=CC(O)=C%10)=C6
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Babcock DF. Examination of the intracellular ionic environment and of ionophore action by null point measurements employing the fluorescein chromophore. J Biol Chem. 1983 May 25;258(10):6380-9.
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