4u8C( IRE1 Inhibitor III )

Catalog No. M11667 CAS No. 14003-96-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

4u8C
Note

Research use only, not for human use.
Brief Description

4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.
Description

4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.
In Vitro

——
In Vivo

Animal Model:ApoE-/- mice Dosage:10 mg/kg Administration:I.p. injection; daily; for 4 more weeks Result:Led to a significant reduction (45.2%) in atherosclerotic lesion area in en face aorta preparations.
Synonyms

IRE1 Inhibitor III
Pathway

Others
Target

Other Targets
Recptor

IRE1 RN/Ase
Research Area

Other Indications
Indication

——

CAS Number

14003-96-4
Formula Weight

204.18
Molecular Formula

C11H8O4
Purity

>98% (HPLC)
Solubility

DMSO:19 mg/mL (93.05 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)
SMILES

O=CC1=C(O2)C(C(C)=CC2=O)=CC=C1O
Chemical Name

7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde

1. Cross BC, et al. Proc natl Acad Sci U S A. 2012, 109(15), E869-878.

Calculator

molnova catalog