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48740 RP
CAS No. 93363-11-2
48740 RP( RP-55778 | RP-48740 | RP 55779 | RP 55778 )
Catalog No. M26031 CAS No. 93363-11-2
48740 RP is an antagonist of platelet-activating factor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 567 | In Stock |
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| 5MG | 567 | In Stock |
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| 10MG | 906 | In Stock |
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| 25MG | 1340 | In Stock |
|
| 50MG | 1776 | In Stock |
|
| 100MG | 2381 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name48740 RP
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NoteResearch use only, not for human use.
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Brief Description48740 RP is an antagonist of platelet-activating factor.
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Description48740 RP is an antagonist of platelet-activating factor.(In Vivo):48740 RP significantly reduces capillary permeability. 48740 RP increases the number of platelets at a time corresponding to 2 and 4 h after the exposure to lipopolysaccharide (LPS) and the number of eosinophils is also slightly increased. 48740 RP in combination with the LPS exposure increases the number of neutrophils by about half at 24 h.
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In Vitro——
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In Vivo48740 RP (RP-55778) is a platelet-activating factor (PAF) antagonist. In animals treated with 48740 RP only, the number of platelets is increased at a time corresponding to 2 and 4 h after the exposure to lipopolysaccharide (LPS) and the number of eosinophils is also slightly increased. Treatment with 48740 RP in combination with the LPS exposure does not influence the increase in neutrophils seen 2 and 4 h after exposure. At 24 h the increase in the number of neutrophils is about half that in control animals. No effects are found on the LPS-induced increase in number of platelets. In animals pretreated with 48740 RP, there is a significant reduction in capillary permeability.
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SynonymsRP-55778 | RP-48740 | RP 55779 | RP 55778
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PathwayOthers
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TargetPlatelet aggregation
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RecptorBacterial| P-gp?(P-glycoprotein)
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Research Area——
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Indication——
Chemical Information
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CAS Number93363-11-2
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Formula Weight245.3
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Molecular FormulaC12H11N3OS
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Purity>98% (HPLC)
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Solubility——
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SMILESNC(=O)c1ccn2C(SCc12)c1cccnc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cutler RR, et al. The effect of polyoxyethylene stearate (POES) on the growth of mycobacteria in radiometric 7H12 Middlebrook TB medium. Tubercle. 1987 Sep;68(3):209-20.
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