4-methoxylonchocarpin

CAS No. 51589-67-4

4-methoxylonchocarpin( —— )

Catalog No. M37846 CAS No. 51589-67-4

4-methoxylonchocarpin was isolated from the roots of Abrus precatorius as a potent anti-inflammatory compound.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 296 Get Quote
5MG 466 Get Quote
10MG 679 Get Quote
25MG 1003 Get Quote
50MG 1362 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    4-methoxylonchocarpin
  • Note
    Research use only, not for human use.
  • Brief Description
    4-methoxylonchocarpin was isolated from the roots of Abrus precatorius as a potent anti-inflammatory compound.
  • Description
    4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to Toll-like Receptor (TLR) TLR4 to inhibit NF-κB activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    NF-κB | TNF
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    51589-67-4
  • Formula Weight
    336.38
  • Molecular Formula
    C21H20O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OC1=C2C(OC(C)(C)C=C2)=CC=C1C(/C=C/C3=CC=C(OC)C=C3)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jang HM, et al. 4-Methoxylonchocarpin attenuates inflammation by inhibiting lipopolysaccharide binding to Toll-like receptor of macrophages and M1 macrophage polarization. Int Immunopharmacol. 2017 Apr;45:90-97.?
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