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Home - Products - Microbiology/Virology - HCV - 4-Phenoxybenzylamine

4-Phenoxybenzylamine

CAS No. 107622-80-0

4-Phenoxybenzylamine( —— )

Catalog No. M20512 CAS No. 107622-80-0

4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against HCV NS3/4a .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    4-Phenoxybenzylamine
  • Note
    Research use only, not for human use.
  • Brief Description
    4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against HCV NS3/4a .
  • Description
    4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against HCV NS3/4a .
  • In Vitro
    A highly conserved novel binding site located at the interface between the protease and helicase domains of the Hepatitis C Virus (HCV) NS3 protein is identified. 4-Phenoxybenzylamine binding at this allosteric site inhibits the function of the NS3 protein by stabilizing an inactive conformation and thus represents a new class of direct acting antiviral agents.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    HCV
  • Recptor
    HCV NS3/4A
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    107622-80-0
  • Formula Weight
    199.25
  • Molecular Formula
    C13H13NO
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 12.5 mg/mL (62.74 mM)
  • SMILES
    NCc1ccc(Oc2ccccc2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Saalau-Bethell S M Woodhead A J Chessari G et al. Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function[J]. Nature Chemical Biology 2012 8(11):2354.
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