4-PQBH( —— )

Catalog No. M35557 CAS No. 2243355-51-1

4-PQBH is a potent Nur77-binding agent with antitumour activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

4-PQBH
Note

Research use only, not for human use.
Brief Description

4-PQBH is a potent Nur77-binding agent with antitumour activity.
Description

4-PQBH is a potent Nur77 binder (KD=1.17 μM). 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

2243355-51-1
Formula Weight

367.4
Molecular Formula

C22H17N5O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (68.05 mM; Ultrasonic )
SMILES

O=C(NN=CC=1C=CN=CC1)C2=CC=C(C=C2)NC=3C=CN=C4C=CC=CC43
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Baicun Li, et al. Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma. Bioorg Chem. 2022 Apr;121:105651.?

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