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Home - Products - Endocrinology/Hormones - Estrogen Receptor/ERR - 4-Hydroxytamoxifen

4-Hydroxytamoxifen

CAS No. 68392-35-8

4-Hydroxytamoxifen ( Afimoxifene )

Catalog No. M15614 CAS No. 68392-35-8

A selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    4-Hydroxytamoxifen
  • Note
    Research use only, not for human use.
  • Brief Description
    A selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen.
  • Description
    A selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen; exhibits more potent estrogen agonist/antagonist activity and can inhibit MCF-7 and MDA-MB-231 cell proliferation with IC50 values of 27 and 18 uM, respectively.Breast Cancer Phase 2 Clinical
  • Synonyms
    Afimoxifene
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    Others
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    68392-35-8
  • Formula Weight
    387.51
  • Molecular Formula
    C26H29NO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 71 mg/mL (183.2 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    OC1=CC=C(/C(C2=CC=C(OCCN(C)C)C=C2)=C(C3=CC=CC=C3)/CC)C=C1
  • Chemical Name
    (Z)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mansel R, et al. Breast Cancer Res Treat. 2007 Dec;106(3):389-97.
2. Desta Z, et al. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
3. Seeger H, et al. Horm Metab Res. 2004 May;36(5):277-80.
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