4-Hydroxytamoxifen

CAS No. 68392-35-8

4-Hydroxytamoxifen( Afimoxifene )

Catalog No. M15614 CAS No. 68392-35-8

A selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 42 In Stock
10MG 65 In Stock
25MG 116 In Stock
50MG 192 In Stock
100MG 295 In Stock
200MG 444 In Stock
500MG 710 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    4-Hydroxytamoxifen
  • Note
    Research use only, not for human use.
  • Brief Description
    A selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen.
  • Description
    A selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen; exhibits more potent estrogen agonist/antagonist activity and can inhibit MCF-7 and MDA-MB-231 cell proliferation with IC50 values of 27 and 18 uM, respectively.Breast Cancer Phase 2 Clinical
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Afimoxifene
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    Others
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    68392-35-8
  • Formula Weight
    387.5139
  • Molecular Formula
    C26H29NO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 71 mg/mL (183.2 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    OC1=CC=C(/C(C2=CC=C(OCCN(C)C)C=C2)=C(C3=CC=CC=C3)/CC)C=C1
  • Chemical Name
    (Z)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mansel R, et al. Breast Cancer Res Treat. 2007 Dec;106(3):389-97. 2. Desta Z, et al. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75. 3. Seeger H, et al. Horm Metab Res. 2004 May;36(5):277-80.
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