4-Hydroxycoumarin
CAS No. 1076-38-6
4-Hydroxycoumarin ( —— )
Catalog No. M22660 CAS No. 1076-38-6
4-Hydroxycoumarin, a coumarin derivative.4-Hydroxycoumarin serves as an immediate precursor of 4-hydroxycoumarin (4HC) type anticoagulants (for example, warfarin).?4-Hydroxycoumarin derivatives ?are employed as the anticoagulant, antibacterial, antifungal, antiviral, antitumor, antiprotozoal, insecticidal, antimycobacterial, antimutagenic, antioxidant, anti-inflammatory agents, HIV protease inhibitors and tyrosine kinase inhibitors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Name4-Hydroxycoumarin
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NoteResearch use only, not for human use.
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Brief Description4-Hydroxycoumarin, a coumarin derivative.4-Hydroxycoumarin serves as an immediate precursor of 4-hydroxycoumarin (4HC) type anticoagulants (for example, warfarin).?4-Hydroxycoumarin derivatives ?are employed as the anticoagulant, antibacterial, antifungal, antiviral, antitumor, antiprotozoal, insecticidal, antimycobacterial, antimutagenic, antioxidant, anti-inflammatory agents, HIV protease inhibitors and tyrosine kinase inhibitors.
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Description4-Hydroxycoumarin, a coumarin derivative.4-Hydroxycoumarin serves as an immediate precursor of 4-hydroxycoumarin (4HC) type anticoagulants (for example, warfarin).?4-Hydroxycoumarin derivatives ?are employed as the anticoagulant, antibacterial, antifungal, antiviral, antitumor, antiprotozoal, insecticidal, antimycobacterial, antimutagenic, antioxidant, anti-inflammatory agents, HIV protease inhibitors and tyrosine kinase inhibitorsThe antioxidant activity of 4-Hydroxycoumarin synthetic derivatives and 4-methylumbelliferone were determined taking 4-Hydroxycoumarin as the reference compound. METHODS AND RESULTS:Six 3-aryl-4-Hydroxycoumarin derivatives were synthesized from 4-Hydroxycoumarin as precursor in order to evaluate changes in their antioxidant properties due to C3-aryl substituent nature. Free radical scavenging capacities of these compounds against two different species DPPH(·) and ABTS(·+) and the protecting ability towards the β-carotene-linoleic acid co-oxidation enzymatically induced by lipoxygenase were measured. In addition, the relationship between the activities of these molecules against DPPH radical and the bond dissociation energy of O-H (BDE) calculated using methods of computational chemistry was evaluated.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetAChR
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RecptorAChR
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Research Area——
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Indication——
Chemical Information
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CAS Number1076-38-6
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Formula Weight162.14
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Molecular FormulaC9H6O3
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Purity>98% (HPLC)
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SolubilityDMSO:247 mg/mL (1523.37 mM; Need ultrasonic)
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SMILESOc1cc(=O)oc2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Effect of different C3-aryl substituents on the antioxidant activity of 4-hydroxycoumarin derivatives. Bioorg Med Chem. 2011 Nov 1;19(21):6233-8.
molnova catalog
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