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4-CPPC

CAS No. 29553-70-6

4-CPPC( —— )

Catalog No. M28169 CAS No. 29553-70-6

4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50= 27 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    4-CPPC
  • Note
    Research use only, not for human use.
  • Brief Description
    4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50= 27 μM).
  • Description
    4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50= 27 μM).1It is selective for MIF-2 over MIF-1 (IC50= 450 μM). It inhibits MIF-2, but not MIF-1, binding to CD74in vitrowhen used at a concentration of 10 μM. 4-CPPC (5, 10, and 25 μM) inhibits MIF-2-induced ERK1/2 phosphorylation in primary human skin fibroblasts.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PXR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    29553-70-6
  • Formula Weight
    287.227
  • Molecular Formula
    C14H9NO6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (348.17 mM)
  • SMILES
    OC(=O)c1cccc(c1)-c1cc(ncc1C(O)=O)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lin W, et, al. SPA70 is a potent antagonist of human pregnane X receptor. Nat Commun. 2017 Sep 29;8(1):741.
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