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4-Butylresorcinol

CAS No. 18979-61-8

4-Butylresorcinol( Butylresorcinol )

Catalog No. M20556 CAS No. 18979-61-8

4-Butylresorcinol is a potent inhibitor of tyrosinase(IC50 : 11.27 μM) and is used in cosmetics as a depigmenting agent.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    4-Butylresorcinol
  • Note
    Research use only, not for human use.
  • Brief Description
    4-Butylresorcinol is a potent inhibitor of tyrosinase(IC50 : 11.27 μM) and is used in cosmetics as a depigmenting agent.
  • Description
    4-Butylresorcinol is a potent inhibitor of tyrosinase(IC50 : 11.27 μM) and is used in cosmetics as a depigmenting agent.
  • In Vitro
    It shows that 4-Butylresorcinol (4-n-butylresorcinol) significantly inhibits melanin synthesis in a concentration-dependent manner. In addition, it is also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme. 4-Butylresorcinol does not induce ERK, Akt activation, or MITF degradation, and has no effect on cAMP response element binding protein (CREB) phosphorylation, which stimulates MITF expression.4-Butylresorcinol strongly reduces tyrosinase activity in a cell-free system. Moreover, 4-Butylresorcinol shows an additive effect in combination with hinokitiol, which reduces MITF expression.
  • In Vivo
    ——
  • Synonyms
    Butylresorcinol
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Tyrosinase
  • Recptor
    Tyrosinase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    18979-61-8
  • Formula Weight
    166.22
  • Molecular Formula
    C10H14O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:150 mg/mL (902.42 mM)
  • SMILES
    CCCCc1ccc(O)cc1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kim D S Kim S Y Park S H et al. Inhibitory Effects of 4-n-Butylresorcinol on Tyrosinase Activity and Melanin Synthesis[J]. Biological & Pharmaceutical Bulletin 2005 28(12):2216-2219.
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