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3-Chloro-L-Tyrosine

CAS No. 7423-93-0

3-Chloro-L-Tyrosine ( 3-Chlorotyrosine;Chlorotyrosine )

Catalog No. M20026 CAS No. 7423-93-0

3-Chlorotyrosine a specific marker of myeloperoxidase-catalyzed oxidation is markedly elevated in low-density lipoprotein isolated from human atherosclerotic intima. In particular myeloperoxidase halogenates tyrosine residues in plasma proteins and generates 3-chlorotyrosine (CY).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    3-Chloro-L-Tyrosine
  • Note
    Research use only not for human use.
  • Brief Description
    3-Chlorotyrosine a specific marker of myeloperoxidase-catalyzed oxidation is markedly elevated in low-density lipoprotein isolated from human atherosclerotic intima. In particular myeloperoxidase halogenates tyrosine residues in plasma proteins and generates 3-chlorotyrosine (CY).
  • Description
    3-Chlorotyrosine a specific marker of myeloperoxidase-catalyzed oxidation is markedly elevated in low-density lipoprotein isolated from human atherosclerotic intima. In particular myeloperoxidase halogenates tyrosine residues in plasma proteins and generates 3-chlorotyrosine (CY). The detection of free chlorotyrosine in blood or urine arises from the degradation of these chlorinated proteins. CY concentrations may be useful for monitoring the activation of neutrophils in asthmatic patients.
  • Synonyms
    3-Chlorotyrosine;Chlorotyrosine
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    7423-93-0
  • Formula Weight
    215.63
  • Molecular Formula
    C9H10ClNO3
  • Purity
    >98% (HPLC)
  • Solubility
    Water:41.7 mM
  • SMILES
    N[C@@H](Cc1ccc(O)c(Cl)c1)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hazen SL et al. 3-Chlorotyrosine a specific marker of myeloperoxidase-catalyzed oxidation is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. J Clin Invest. 1997 May 1;99(9):2075-81.
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