
27-Hydroxycholesterol
CAS No. 20380-11-4
27-Hydroxycholesterol( —— )
Catalog No. M29620 CAS No. 20380-11-4
27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 155 | Get Quote |
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10MG | 230 | Get Quote |
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25MG | 390 | Get Quote |
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50MG | 565 | Get Quote |
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100MG | Get Quote | Get Quote |
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Biological Information
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Product Name27-Hydroxycholesterol
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NoteResearch use only, not for human use.
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Brief Description27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
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Description27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.(In Vitro):27-Hydroxycholesterol, through estrogen receptor activation, triggers a deleterious effect in prostate cancer cell lines. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors . 27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator that displays significant partial agonist activity in a variety of cellular models of estrogen receptor action. It positively regulates both gene transcription and cell proliferation in cellular models of breast cancer . 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol levels can be modulated by statins or direct inhibition of CYP27A1, thereby attenuating its pro-tumorigenic activities . 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload .
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In Vitro27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator that displays significant partial agonist activity in a variety of cellular models of estrogen receptor action. It positively regulates both gene transcription and cell proliferation in cellular models of breast cancer. 27-Hydroxycholesterol, through estrogen receptor activation, triggers deleterious effect in prostate cancer cell lines. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors. 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol also acts as an endogenous selective estrogen receptor modulator capable of increasing breast cancer growth and metastasis. 27-Hydroxycholesterol levels can be modulated by statins or direct inhibition of CYP27A1, thereby attenuating its pro-tumorigenic activities. 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload.
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In Vivo——
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorEstrogen/progestogen Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number20380-11-4
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Formula Weight402.663
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Molecular FormulaC27H46O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?Ethanol : 16.67 mg/mL (41.40 )
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SMILES[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC[C@@H](C)CO
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog



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