27-Hydroxycholesterol

CAS No. 20380-11-4

27-Hydroxycholesterol( —— )

Catalog No. M29620 CAS No. 20380-11-4

27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 155 Get Quote
10MG 230 Get Quote
25MG 390 Get Quote
50MG 565 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
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Biological Information

  • Product Name
    27-Hydroxycholesterol
  • Note
    Research use only, not for human use.
  • Brief Description
    27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
  • Description
    27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.(In Vitro):27-Hydroxycholesterol, through estrogen receptor activation, triggers a deleterious effect in prostate cancer cell lines. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors . 27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator that displays significant partial agonist activity in a variety of cellular models of estrogen receptor action. It positively regulates both gene transcription and cell proliferation in cellular models of breast cancer . 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol levels can be modulated by statins or direct inhibition of CYP27A1, thereby attenuating its pro-tumorigenic activities . 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload .
  • In Vitro
    27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator that displays significant partial agonist activity in a variety of cellular models of estrogen receptor action. It positively regulates both gene transcription and cell proliferation in cellular models of breast cancer. 27-Hydroxycholesterol, through estrogen receptor activation, triggers deleterious effect in prostate cancer cell lines. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors. 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol also acts as an endogenous selective estrogen receptor modulator capable of increasing breast cancer growth and metastasis. 27-Hydroxycholesterol levels can be modulated by statins or direct inhibition of CYP27A1, thereby attenuating its pro-tumorigenic activities. 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    Estrogen/progestogen Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    20380-11-4
  • Formula Weight
    402.663
  • Molecular Formula
    C27H46O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?Ethanol : 16.67 mg/mL (41.40 )
  • SMILES
    [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC[C@@H](C)CO
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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