2614W94

CAS No. 205187-35-5

2614W94 ( —— )

Catalog No. M26022 CAS No. 205187-35-5

2614W94 is a selective, competitive, and reversible inhibitor of monoamine oxidase-A with IC50 of 5 nM and Ki of 1.6 nM with serotonin as a substrate.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 447 In Stock
10MG 651 In Stock
25MG 1017 In Stock
50MG 1368 In Stock
100MG 1782 In Stock
500MG 3573 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    2614W94
  • Note
    Research use only, not for human use.
  • Brief Description
    2614W94 is a selective, competitive, and reversible inhibitor of monoamine oxidase-A with IC50 of 5 nM and Ki of 1.6 nM with serotonin as a substrate.
  • Description
    2614W94 is a selective, competitive, and reversible inhibitor of monoamine oxidase-A with IC50 of 5 nM and Ki of 1.6 nM with serotonin as a substrate.(In Vitro):2614W94 (30 nM) shows no inhibition of MAO-B.(In Vivo):In rats, 2614W94 (5 mg/kg, p.o.) selectively inhibits MAO-A in brains and livers and elevates neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a redcution of their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) dose-dependently potentiates 5-hydroxytryptophan-induced head twitches with an extrapolated ED50 of 1.1 mg/kg.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Alkyl-Chain
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    205187-35-5
  • Formula Weight
    344.3
  • Molecular Formula
    C15H11F3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(Oc1ccc2c(Oc3ccccc3S2(=O)=O)c1)C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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