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25CN-NBOH
CAS No. 1391489-32-9
25CN-NBOH( 25CN NBOH )
Catalog No. M11623 CAS No. 1391489-32-9
A potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Name25CN-NBOH
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM.
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DescriptionA potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin); >100-fold over 5-HT2CR and 46-fold selectivity over 5-HT2BR; exhibits 30- to 180-fold 5-HT2A/5-HT2C selectivities and 54-fold 5-HT2A/5-HT2B selectivity in inositol phosphate and intracellular Ca2+ mobilization assays; is a superior selective and brain-penetrant 5-HT2A receptor agonist compared with (±)-2,5-dimethoxy-4-iodoamphetamine (DOI).
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In Vitro——
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In Vivo——
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Synonyms25CN NBOH
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1391489-32-9
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Formula Weight312.369
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Molecular FormulaC18H20N2O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCOC1=CC(=C(C=C1CCNCC2=CC=CC=C2O)OC)C#N.Cl
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Chemical Name2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jensen AA, et al. J Pharmacol Exp Ther. 2017 Jun;361(3):441-453.
2. Fantegrossi WE, et al. Psychopharmacology (Berl). 2015 Mar;232(6):1039-47.
3. Halberstadt AL, et al. Neuropharmacology. 2016 Aug;107:364-375.
4. Hansen M, et al. ACS Chem Neurosci. 2014 Mar 19;5(3):243-9.
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