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25CN-NBOH

CAS No. 1391489-32-9

25CN-NBOH ( 25CN NBOH )

Catalog No. M11623 CAS No. 1391489-32-9

A potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    25CN-NBOH
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM.
  • Description
    A potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin); >100-fold over 5-HT2CR and 46-fold selectivity over 5-HT2BR; exhibits 30- to 180-fold 5-HT2A/5-HT2C selectivities and 54-fold 5-HT2A/5-HT2B selectivity in inositol phosphate and intracellular Ca2+ mobilization assays; is a superior selective and brain-penetrant 5-HT2A receptor agonist compared with (±)-2,5-dimethoxy-4-iodoamphetamine (DOI).
  • Synonyms
    25CN NBOH
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1391489-32-9
  • Formula Weight
    312.37
  • Molecular Formula
    C18H20N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COC1=CC(=C(C=C1CCNCC2=CC=CC=C2O)OC)C#N.Cl
  • Chemical Name
    2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jensen AA, et al. J Pharmacol Exp Ther. 2017 Jun;361(3):441-453.
2. Fantegrossi WE, et al. Psychopharmacology (Berl). 2015 Mar;232(6):1039-47.
3. Halberstadt AL, et al. Neuropharmacology. 2016 Aug;107:364-375.
4. Hansen M, et al. ACS Chem Neurosci. 2014 Mar 19;5(3):243-9.
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