25-Hydroxycholesterol
CAS No. 2140-46-7
25-Hydroxycholesterol ( —— )
Catalog No. M19577 CAS No. 2140-46-7
25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs).
Purity : >98% (HPLC)
Size | Price / USD | Stock | Quantity |
5MG | 41 | In Stock |
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10MG | 55 | In Stock |
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25MG | 84 | In Stock |
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50MG | 128 | In Stock |
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100MG | 201 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product Name25-Hydroxycholesterol
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NoteResearch use only not for human use.
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Brief Description25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs).
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Description25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regulation of cholesterol biosynthesis after an acute dietary cholesterol challenge. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptorother; HMG-CoA Reductase
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Research Area——
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Indication——
Chemical Information
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CAS Number2140-46-7
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Formula Weight402.65
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Molecular FormulaC27H46O2
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Purity>98% (HPLC)
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SolubilityEthanol: 20 mg/mL;Chloroform: 50 mg/mL
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SMILESC[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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20-O-Acetylingenol-3...
20-O-Acetylingenol-3-angelate is a natural compound from Euphorbia lathyris L.
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Lappaol A
Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant anticancer agents.
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PKC ζ pseudosubstrat...
Inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by a disulphide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide. Induces mast cell degranulation by a PKC ζ-independent pathway.