25-Hydroxycholesterol

Research use only not for human use.

25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs).

25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regulation of cholesterol biosynthesis after an acute dietary cholesterol challenge. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

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Others

Other Targets

other; HMG-CoA Reductase

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2140-46-7

402.65

C27H46O2

>98% (HPLC)

Ethanol: 20 mg/mL;Chloroform: 50 mg/mL

C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

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(-20℃)

With Ice Pack

≥ 2 years