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2-Iminobiotin
CAS No. 13395-35-2
2-Iminobiotin( Guanidinobiotin | 2-IMINOBIOTIN HYDROBROMIDE )
Catalog No. M20639 CAS No. 13395-35-2
2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS;?Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 55 | In Stock |
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| 10MG | 82 | In Stock |
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| 25MG | 148 | In Stock |
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| 50MG | 222 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name2-Iminobiotin
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NoteResearch use only, not for human use.
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Brief Description2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS;?Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS respectively).
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Description2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS;?Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS respectively).
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In VitroApplication of low concentrations of 2-Iminobiotin (2-IB; 10 ng/mL and 30 ng/mL) superimposed on hypothermia abrogates the hypoxia-induced lactate dehydrogenase (LDH) increase, resulting in LDH levels that were not different from the normoxia control.
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In Vivo——
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SynonymsGuanidinobiotin | 2-IMINOBIOTIN HYDROBROMIDE
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PathwayImmunology/Inflammation
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TargetNOS
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RecptorNOS
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Research Area——
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Indication——
Chemical Information
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CAS Number13395-35-2
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Formula Weight243.33
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Molecular FormulaC10H17N3O2S??
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Purity>98% (HPLC)
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SolubilityDMSO:12.5 mg/mL (51.37 mM)
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SMILES[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=N)N2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Zitta K Peeters-Scholte C Sommer L et al. 2-Iminobiotin Superimposed on Hypothermia Protects Human Neuronal Cells from Hypoxia-Induced Cell Damage: An in Vitro Study[J]. Frontiers in Pharmacology 2018 8:971.
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