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2-Amino-6-cyclopropylamino-9H-purine

CAS No. 120503-69-7

2-Amino-6-cyclopropylamino-9H-purine ( —— )

Catalog No. M28703 CAS No. 120503-69-7

2-Amino-6-cyclopropylamino-9H-purine,the key intermediate of abacavir was synthesized from ethyl cyanoacetate by nitrosation,cyclization with guanidine hydrochloride in the presence of EtONa and reduction to give 2,4,5-triamino-6-hydroxypyrimidine.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    2-Amino-6-cyclopropylamino-9H-purine
  • Note
    Research use only, not for human use.
  • Brief Description
    2-Amino-6-cyclopropylamino-9H-purine,the key intermediate of abacavir was synthesized from ethyl cyanoacetate by nitrosation,cyclization with guanidine hydrochloride in the presence of EtONa and reduction to give 2,4,5-triamino-6-hydroxypyrimidine.
  • Description
    2-Amino-6-cyclopropylamino-9H-purine,the key intermediate of abacavir was synthesized from ethyl cyanoacetate by nitrosation,cyclization with guanidine hydrochloride in the presence of EtONa and reduction to give 2,4,5-triamino-6-hydroxypyrimidine.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PD-1/PD-L1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    120503-69-7
  • Formula Weight
    190.2
  • Molecular Formula
    C8H10N6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Nc1nc(NC2CC2)c2nc[nH]c2n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wang T, et, al. Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. J Med Chem. 2021 May 30.
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