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Home - Products - Endocrinology/Hormones - Androgen Receptor (AR) - 2,2,5,7,8-Pentamethyl-6-Chromanol

2,2,5,7,8-Pentamethyl-6-Chromanol

CAS No. 950-99-2

2,2,5,7,8-Pentamethyl-6-Chromanol ( PMC )

Catalog No. M25001 CAS No. 950-99-2

2,2,5,7,8-Pentamethyl-6-Chromanol is the anti-oxidant moiety of vitamin E (α-tocopherol), which has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    2,2,5,7,8-Pentamethyl-6-Chromanol
  • Note
    Research use only, not for human use.
  • Brief Description
    2,2,5,7,8-Pentamethyl-6-Chromanol is the anti-oxidant moiety of vitamin E (α-tocopherol), which has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines.
  • Description
    2,2,5,7,8-Pentamethyl-6-Chromanol is the anti-oxidant moiety of vitamin E (α-tocopherol), which has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines.
  • Synonyms
    PMC
  • Pathway
    Endocrinology/Hormones
  • Target
    Androgen Receptor (AR)
  • Recptor
    Androgen Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    950-99-2
  • Formula Weight
    220.3
  • Molecular Formula
    C14H20O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL (1134.76 mM; Need ultrasonic)
  • SMILES
    CC(C)(CC1)Oc(c(C)c2C)c1c(C)c2O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kyriakopoulos CE, et al. A multicenter phase 1/2a dose-escalation study of the antioxidant moiety of vitamin E 2,2,5,7,8-pentamethyl-6-chromanol (APC-100) in men with advanced prostate cancer. Invest New Drugs. 2016 Apr;34(2):225-30.
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