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Home - Products - Metabolic Enzyme/Protease - Dehydrogenase - 11β-HSD1-IN-11

11β-HSD1-IN-11

CAS No. 859721-81-6

11β-HSD1-IN-11( —— )

Catalog No. M35344 CAS No. 859721-81-6

11β-HSd1-in-11 is a potent and competitive inhibitor of 11-β-hydroxysteroid dehydrogenase 1 (11β-HSD1) IN rats and humans with IC50 values of 0.34 μM and 0.13 μM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    11β-HSD1-IN-11
  • Note
    Research use only, not for human use.
  • Brief Description
    11β-HSd1-in-11 is a potent and competitive inhibitor of 11-β-hydroxysteroid dehydrogenase 1 (11β-HSD1) IN rats and humans with IC50 values of 0.34 μM and 0.13 μM, respectively.
  • Description
    11β-HSD1-IN-11 (Compound c1a) is a competitive 11β-HSD1 inhibitor with IC50s of 0.34 μM and 0.13 μM against rat and human 11β-HSD1, respectively.
  • In Vitro
    ——
  • In Vivo
    A single dose of the 11β-HSD1 inhibitor Merck 544 reduced the overall abundance of 11β-HSD1-IN-11 (Compound c1a) (15 mg/kg; oral gavage; once) in the rat liver.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    Dehydrogenase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    859721-81-6
  • Formula Weight
    328.31
  • Molecular Formula
    C15H11F3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    S(CC(=O)C1=CC=C(C(F)(F)F)C=C1)(=O)(=O)C2=CC=CC=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Naredo-Gonzalez G, et al. Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy. Sci Rep. 2022 Sep 29;12(1):16268.?
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