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Home - Products - JAK/STAT Signaling - Pim - 1-phenoxazin-10-ylethanone

1-phenoxazin-10-ylethanone

CAS No. 6192-43-4

1-phenoxazin-10-ylethanone( 10-acetylphenoxazine | N-Acetylphenoxazine | HJ-PI01 )

Catalog No. M28779 CAS No. 6192-43-4

1-phenoxazin-10-ylethanone is a Pim-2 inhibitor. 1-phenoxazin-10-ylethanone induces apoptosis and autophagic cell death in triple-negative human breast cancer.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    1-phenoxazin-10-ylethanone
  • Note
    Research use only, not for human use.
  • Brief Description
    1-phenoxazin-10-ylethanone is a Pim-2 inhibitor. 1-phenoxazin-10-ylethanone induces apoptosis and autophagic cell death in triple-negative human breast cancer.
  • Description
    1-phenoxazin-10-ylethanone is a Pim-2 inhibitor. 1-phenoxazin-10-ylethanone induces apoptosis and autophagic cell death in triple-negative human breast cancer.
  • In Vitro
    Western Blot Analysis Cell Line:MDA-MB-231 cell line Concentration:300 and 460 nmol/L Incubation Time:12, 24, 36 and 48 hours Result:Time-dependently increased LC3-II and Beclin-1 and induced p62 degradation in MDA-MB-231 cells. Increased the level of Bax. Decreased the level of Bcl-2, and Pim-2 and Pim-2 phosphorylation. Activated caspase-9 and caspase-3.
  • In Vivo
    Animal Model:BALB/c female nude mice with MDA-MB-231 cells injection Dosage:40 mg/kg Administration:Oral administration; 40 mg/kg, once daily for 10 days Result:Significantly inhibited tumor growth with an obvious decreasing of the body, liver, spleen and kidney weights of the mice.
  • Synonyms
    10-acetylphenoxazine | N-Acetylphenoxazine | HJ-PI01
  • Pathway
    JAK/STAT Signaling
  • Target
    Pim
  • Recptor
    histone acetyltransferase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6192-43-4
  • Formula Weight
    225.247
  • Molecular Formula
    C14H11NO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (221.99 mM)
  • SMILES
    CC(=O)N1c2ccccc2Oc2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Klotilda Narkaj, et al. Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice. eNeuro. 2018 Nov 8;5(5):ENEURO.0378-18.2018.
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