Cart
sales@molnova.com
Home - Products - JAK/STAT Signaling - Pim - 1-phenoxazin-10-ylethanone

1-phenoxazin-10-ylethanone

CAS No. 6192-43-4

1-phenoxazin-10-ylethanone( 10-acetylphenoxazine | N-Acetylphenoxazine | HJ-PI01 )

Catalog No. M28779 CAS No. 6192-43-4

1-phenoxazin-10-ylethanone is a Pim-2 inhibitor. 1-phenoxazin-10-ylethanone induces apoptosis and autophagic cell death in triple-negative human breast cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 110 Get Quote
10MG 177 Get Quote
25MG 410 Get Quote
50MG 605 Get Quote
100MG 860 Get Quote
500MG 1728 Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    1-phenoxazin-10-ylethanone
  • Note
    Research use only, not for human use.
  • Brief Description
    1-phenoxazin-10-ylethanone is a Pim-2 inhibitor. 1-phenoxazin-10-ylethanone induces apoptosis and autophagic cell death in triple-negative human breast cancer.
  • Description
    1-phenoxazin-10-ylethanone is a Pim-2 inhibitor. 1-phenoxazin-10-ylethanone induces apoptosis and autophagic cell death in triple-negative human breast cancer.
  • In Vitro
    Western Blot Analysis Cell Line:MDA-MB-231 cell line Concentration:300 and 460 nmol/L Incubation Time:12, 24, 36 and 48 hours Result:Time-dependently increased LC3-II and Beclin-1 and induced p62 degradation in MDA-MB-231 cells. Increased the level of Bax. Decreased the level of Bcl-2, and Pim-2 and Pim-2 phosphorylation. Activated caspase-9 and caspase-3.
  • In Vivo
    Animal Model:BALB/c female nude mice with MDA-MB-231 cells injection Dosage:40 mg/kg Administration:Oral administration; 40 mg/kg, once daily for 10 days Result:Significantly inhibited tumor growth with an obvious decreasing of the body, liver, spleen and kidney weights of the mice.
  • Synonyms
    10-acetylphenoxazine | N-Acetylphenoxazine | HJ-PI01
  • Pathway
    JAK/STAT Signaling
  • Target
    Pim
  • Recptor
    histone acetyltransferase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6192-43-4
  • Formula Weight
    225.247
  • Molecular Formula
    C14H11NO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (221.99 mM)
  • SMILES
    CC(=O)N1c2ccccc2Oc2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Klotilda Narkaj, et al. Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice. eNeuro. 2018 Nov 8;5(5):ENEURO.0378-18.2018.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • R8-T198wt

    Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. Displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.

  • CX-6258

    A potent, selective, and orally efficacious pan-Pim inhibitor with IC50 of 5/25/16 nM for Pim1/2/3, respectively.

  • TP-3654

    A potent, selective, orally active second-generation PIM inhibitor with Ki of 5, 42 and 239 nM for Pim1, 2 and 3, respectively.

Sign In Join Free