
1-phenoxazin-10-ylethanone
CAS No. 6192-43-4
1-phenoxazin-10-ylethanone( 10-acetylphenoxazine | N-Acetylphenoxazine | HJ-PI01 )
Catalog No. M28779 CAS No. 6192-43-4
1-phenoxazin-10-ylethanone is a Pim-2 inhibitor. 1-phenoxazin-10-ylethanone induces apoptosis and autophagic cell death in triple-negative human breast cancer.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 110 | Get Quote |
![]() ![]() |
10MG | 177 | Get Quote |
![]() ![]() |
25MG | 410 | Get Quote |
![]() ![]() |
50MG | 605 | Get Quote |
![]() ![]() |
100MG | 860 | Get Quote |
![]() ![]() |
500MG | 1728 | Get Quote |
![]() ![]() |
1G | Get Quote | Get Quote |
![]() ![]() |
Biological Information
-
Product Name1-phenoxazin-10-ylethanone
-
NoteResearch use only, not for human use.
-
Brief Description1-phenoxazin-10-ylethanone is a Pim-2 inhibitor. 1-phenoxazin-10-ylethanone induces apoptosis and autophagic cell death in triple-negative human breast cancer.
-
Description1-phenoxazin-10-ylethanone is a Pim-2 inhibitor. 1-phenoxazin-10-ylethanone induces apoptosis and autophagic cell death in triple-negative human breast cancer.
-
In VitroWestern Blot Analysis Cell Line:MDA-MB-231 cell line Concentration:300 and 460 nmol/L Incubation Time:12, 24, 36 and 48 hours Result:Time-dependently increased LC3-II and Beclin-1 and induced p62 degradation in MDA-MB-231 cells. Increased the level of Bax. Decreased the level of Bcl-2, and Pim-2 and Pim-2 phosphorylation. Activated caspase-9 and caspase-3.
-
In VivoAnimal Model:BALB/c female nude mice with MDA-MB-231 cells injection Dosage:40 mg/kg Administration:Oral administration; 40 mg/kg, once daily for 10 days Result:Significantly inhibited tumor growth with an obvious decreasing of the body, liver, spleen and kidney weights of the mice.
-
Synonyms10-acetylphenoxazine | N-Acetylphenoxazine | HJ-PI01
-
PathwayJAK/STAT Signaling
-
TargetPim
-
Recptorhistone acetyltransferase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number6192-43-4
-
Formula Weight225.247
-
Molecular FormulaC14H11NO2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 50 mg/mL (221.99 mM)
-
SMILESCC(=O)N1c2ccccc2Oc2ccccc12
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Klotilda Narkaj, et al. Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice. eNeuro. 2018 Nov 8;5(5):ENEURO.0378-18.2018.
molnova catalog



related products
-
GSK2200150A
GSK2200150A, identified by high-throughput screening (HTS) campaign, is an anti-tuberculosis (TB) agent.
-
Pim inhibitor 28
Pim inhibitor 28 is a potent, selective inhibitor of Pim1/2 with IC50 of 0.05 nM.
-
HS56
HS56 (Pim-DAPK3 inhibitor HS56) is a potent, dual Pim/DAPK3 inhibitor with Ki of 72 nM (Pim-3) and 315 nM (DAPK3).