1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
CAS No. 4004-05-1
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine ( DOPE )
Catalog No. M22918 CAS No. 4004-05-1
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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100MG | 87 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product Name1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
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NoteResearch use only, not for human use.
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Brief Description1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.
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Description1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.Each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent). With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effect on macrophages and DCs and Liposome-containing DOPE shows fusogenicity. LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells.
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SynonymsDOPE
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number4004-05-1
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Formula Weight744.03
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Molecular FormulaC41H78NO8P
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Purity>98% (HPLC)
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SolubilityDMSO:31.25 mg/mL (42.00 mM; Need ultrasonic)
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SMILESO=P(OC[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)(OCCN)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Uemura Y, et al. The efficiency of lipid nanoparticles with an original cationic lipid as a siRNA delivery system for macrophages and dendritic cells.Pharm Dev Technol.2019 Mar;24(3):263-268.
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