(S,R,S)-AHPC-Me

CAS No. 1948273-02-6

(S,R,S)-AHPC-Me ( VHL ligand 2; E3 ligase Ligand 1A )

Catalog No. M28565 CAS No. 1948273-02-6

(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 35 In Stock
25MG 65 In Stock
50MG 98 In Stock
100MG 147 In Stock
200MG 219 In Stock
500MG 357 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    (S,R,S)-AHPC-Me
  • Note
    Research use only, not for human use.
  • Brief Description
    (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771.
  • Description
    (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
  • Synonyms
    VHL ligand 2; E3 ligase Ligand 1A
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    α1A-adrenergic receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1948273-02-6
  • Formula Weight
    444.6
  • Molecular Formula
    C23H32N4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(cc1)-c1scnc1C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Williams TJ, et al. In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists. Br J Pharmacol. 1999 May;127(1):252-8.
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