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(S,R,S)-AHPC-Me
CAS No. 1948273-02-6
(S,R,S)-AHPC-Me ( VHL ligand 2; E3 ligase Ligand 1A )
Catalog No. M28565 CAS No. 1948273-02-6
(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 35 | In Stock |
|
| 25MG | 65 | In Stock |
|
| 50MG | 98 | In Stock |
|
| 100MG | 147 | In Stock |
|
| 200MG | 219 | In Stock |
|
| 500MG | 357 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name(S,R,S)-AHPC-Me
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NoteResearch use only, not for human use.
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Brief Description(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771.
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Description(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
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SynonymsVHL ligand 2; E3 ligase Ligand 1A
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PathwayOthers
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TargetOther Targets
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Recptorα1A-adrenergic receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1948273-02-6
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Formula Weight444.6
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Molecular FormulaC23H32N4O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESC[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(cc1)-c1scnc1C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Williams TJ, et al. In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists. Br J Pharmacol. 1999 May;127(1):252-8.
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