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(S)-MCPG

CAS No. 150145-89-4

(S)-MCPG( —— )

Catalog No. M33187 CAS No. 150145-89-4

(S)-MCPG ((+)-MCPG) is a class I/II metabotropic glutamate receptors (mGluRs) antagonist that blocks spatial learning and long-term enhancement of the dentate gyrus in vivo in rats, and can be used to study neurological disorders.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    (S)-MCPG
  • Note
    Research use only, not for human use.
  • Brief Description
    (S)-MCPG ((+)-MCPG) is a class I/II metabotropic glutamate receptors (mGluRs) antagonist that blocks spatial learning and long-term enhancement of the dentate gyrus in vivo in rats, and can be used to study neurological disorders.
  • Description
    (S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor(mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371). (S)-MCPG can be used for the study of the function of mGluRs in spatial learning.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Lister-Hooded rats in the learning of the Morris water mazeDosage:20 μg Administration:Intraventricular injection; 20 μg; 4 days Result:Impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not.
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    GluR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    150145-89-4
  • Formula Weight
    209.2
  • Molecular Formula
    C10H11NO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?1M NaOH : 22 mg/mL (105.16 mM; ultrasonic and adjust pH to 11 with NaOH)
  • SMILES
    C[C@@](N)(C(O)=O)c1ccc(cc1)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bernadett Boda, et al. Reversal of activity-mediated spine dynamics and learning impairment in a mouse model of Fragile X syndrome. Eur J Neurosci. 2014 Apr;39(7):1130-7.?
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