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(Rac)-Acolbifene

CAS No. 151533-34-5

(Rac)-Acolbifene( EM-343 | (Rac)-EM-652 )

Catalog No. M26408 CAS No. 151533-34-5

(Rac)-Acolbifene is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    (Rac)-Acolbifene
  • Note
    Research use only, not for human use.
  • Brief Description
    (Rac)-Acolbifene is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities.
  • Description
    (Rac)-Acolbifene is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities.(In Vitro):In T-47D cells, (Rac)-Acolbifene (0.110 nM) inhibits cell growth with an IC50 value of 0.110 nM.(In Vivo):In ovariectomized mice, (Rac)-Acolbifene (7.5 nM, 75 nM; oral) shows shows 63% and 84% antiuterotrophic inhibitions, respectively.
  • In Vitro
    (Rac)-Acolbifene (EM-343; (Rac)-EM-652)? shows a inhibitory effect in T-47D cells with an IC50 value of 0.110 nM. Cell Viability Assay Cell Line:T-47D cells Concentration:0.110 nM Incubation Time:72 hours Result:Inhibited T-47D cells growth.
  • In Vivo
    (Rac)-Acolbifene (orally adminstration; 7.5 nM, 75 nM; 9 days; once daily) shows a good pharmacological profile in ovariectomized mice, shows 63% and 84% antiuterotrophic inhibitions at the 7.5 and 75 nM doses, respectively (PK study, ovariectomized mice).
  • Synonyms
    EM-343 | (Rac)-EM-652
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    FGFR1| FGFR2| FLT3| PDGFR| VEGFR1| VEGFR2| VEGFR3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    151533-34-5
  • Formula Weight
    457.57
  • Molecular Formula
    C29H31NO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (218.55 mM)
  • SMILES
    CC1=C(C(Oc2cc(O)ccc12)c1ccc(OCCN2CCCCC2)cc1)c1ccc(O)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Tovar C, et al. Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy. Cell Cycle. 2010 Aug 15;9(16):3364-75.
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