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(R)-ZINC-3573

CAS No. 2089389-15-9

(R)-ZINC-3573( —— )

Catalog No. M34478 CAS No. 2089389-15-9

(R)-ZINC-3573 is a potent and highly selective MRGPRX2 probe that activates endogenous MRGPRX2 in a human mast cell line, inducing degranulation and calcium release.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    (R)-ZINC-3573
  • Note
    Research use only, not for human use.
  • Brief Description
    (R)-ZINC-3573 is a potent and highly selective MRGPRX2 probe that activates endogenous MRGPRX2 in a human mast cell line, inducing degranulation and calcium release.
  • Description
    (R)-ZINC-3573 is a selective Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist with an EC50 value of 740 nM. (R)-ZINC-3573 can be used as a MRGPRX2 probe for the research of pain and itch.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    MRGPR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2089389-15-9
  • Formula Weight
    307.39
  • Molecular Formula
    C18H21N5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (162.66 mM; Ultrasonic (<60°C)
  • SMILES
    CN(C)[C@@H]1CCN(C1)c1cc(nc2ccnn12)-c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lansu K, et al. In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat Chem Biol. 2017 May;13(5):529-536.?
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