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(R)-ZINC-3573

CAS No. 2089389-15-9

(R)-ZINC-3573( —— )

Catalog No. M34478 CAS No. 2089389-15-9

(R)-ZINC-3573 is a potent and highly selective MRGPRX2 probe that activates endogenous MRGPRX2 in a human mast cell line, inducing degranulation and calcium release.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

(R)-ZINC-3573
Note

Research use only, not for human use.
Brief Description

(R)-ZINC-3573 is a potent and highly selective MRGPRX2 probe that activates endogenous MRGPRX2 in a human mast cell line, inducing degranulation and calcium release.
Description

(R)-ZINC-3573 is a selective Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist with an EC50 value of 740 nM. (R)-ZINC-3573 can be used as a MRGPRX2 probe for the research of pain and itch.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

MRGPR
Research Area

——
Indication

——

Chemical Information

CAS Number

2089389-15-9
Formula Weight

307.39
Molecular Formula

C18H21N5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (162.66 mM; Ultrasonic (<60°C)
SMILES

CN(C)[C@@H]1CCN(C1)c1cc(nc2ccnn12)-c1ccccc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Lansu K, et al. In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat Chem Biol. 2017 May;13(5):529-536.?

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