
(R)-STU104
CAS No. 2767124-77-4
(R)-STU104( —— )
Catalog No. M35452 CAS No. 2767124-77-4
(R)-STU104 is a novel TAK1-MKK3 protein-protein interaction (PPI) inhibitor that inhibits TNF-α and suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signalling pathway by binding to MKK3 and disrupting TAK1 phosphorylation of MKK3.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 112 | Get Quote |
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5MG | 170 | Get Quote |
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10MG | 258 | Get Quote |
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25MG | 430 | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product Name(R)-STU104
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NoteResearch use only, not for human use.
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Brief Description(R)-STU104 is a novel TAK1-MKK3 protein-protein interaction (PPI) inhibitor that inhibits TNF-α and suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signalling pathway by binding to MKK3 and disrupting TAK1 phosphorylation of MKK3.
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Description(R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC50s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. (R)-STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R)-STU104 can be used for researching ulcerative colitis.
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In Vitro(R)-STU104 attenuates phosphorylation levels of Mnk1, MK2, and elF4E, leading to the downregulation of TNF-α expression and production.
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In Vivo(R)-STU104 (1, 3 and 10 mg/kg; IG for 7 days) ameliorates the symptoms of DSS-induced experimental colitis in mice, and significantly inhibits inflammatory cytokine protein.Pharmacokinetic Parameters of (R)-STU104 in male C57 mice.Animal Model:C57BL/6 mice (dextran sodium sulfate (DSS)-induced acute ulcerative colitis) Dosage:1, 3 and 10 mg/kg Administration:IG, for 7 days Result:Ameliorated the symptoms of DSS-induced experimental colitis, and significantly inhibited inflammatory cytokine protein TNF-α, IL-1β, IL-6, and IL-23.
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Synonyms——
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PathwayApoptosis
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TargetTNF
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RecptorTNF | MAPK
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Research Area——
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Indication——
Chemical Information
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CAS Number2767124-77-4
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Formula Weight298.33
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Molecular FormulaC18H18O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO(C)C1=C2[C@H](CC(=O)C2=CC(OC)=C1)C3=CC=C(OC)C=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tang ML, et al. Discovery of First-in-Class TAK1-MKK3 Protein-Protein Interaction (PPI) Inhibitor (R)-STU104 for the Treatment of Ulcerative Colitis through Modulating TNF-α Production. J Med Chem. 2022 May 12;65(9):6690-6709.?
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