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(R)-BI-2852
CAS No. 2375482-49-6
(R)-BI-2852( —— )
Catalog No. M36442 CAS No. 2375482-49-6
(R)-BI-2852 can be used as (R)-5-isoindolin-1-one is used as an inhibitor of the RAS family of proteins and as a compound for the treatment and prevention of tumours. (R)-BI-2852 has Antiproliferative and antitumour agent activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 216 | Get Quote |
|
| 5MG | 259 | Get Quote |
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| 10MG | 407 | Get Quote |
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| 25MG | 638 | Get Quote |
|
| 50MG | 886 | Get Quote |
|
| 100MG | 1161 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product Name(R)-BI-2852
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NoteResearch use only, not for human use.
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Brief Description(R)-BI-2852 can be used as (R)-5-isoindolin-1-one is used as an inhibitor of the RAS family of proteins and as a compound for the treatment and prevention of tumours. (R)-BI-2852 has Antiproliferative and antitumour agent activity.
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Description(R)-BI-2852 is the inactive isomer of BI-2852 (HY-126247), and can be used as an experimental control. BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetRas
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RecptorRas
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Research Area——
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Indication——
Chemical Information
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CAS Number2375482-49-6
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Formula Weight516.59
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Molecular FormulaC31H28N6O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC(NCC=1C=C2N(CC3=CN(C)C=N3)C=CC2=CC1)C4=C(C=5C(N4)=CC=CC5)[C@H]6C=7C(C(=O)N6)=CC=C(O)C7
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dirk Kessler, et al. Drugging all RAS isoforms with one pocket. FUTURE MEDICINAL CHEMISTRY
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