A simple DBCO-containing building block used to derivatize carboxyl groups in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) with DBCO moiety through a stable amide bond.

N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction .

Aminooxy-PEG3-azide is an ADC linker belonging to the class of PEGs, as well as three-unit PEGs, which can be used for the synthesis of antibody-coupled reactive molecules (ADCs).