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(1R,2R)-ML-SI3
CAS No. 2418594-00-8
(1R,2R)-ML-SI3( —— )
Catalog No. M35635 CAS No. 2418594-00-8
(1R,2R)-ML-SI3 ((-)-trans-ML-SI3) is a selective TRPML1, TRPML2, and TRPML3 inhibitor for the study of neurodegenerative and cardiovascular diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 1021 | Get Quote |
|
| 50MG | 1334 | Get Quote |
|
| 100MG | 2088 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product Name(1R,2R)-ML-SI3
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NoteResearch use only, not for human use.
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Brief Description(1R,2R)-ML-SI3 ((-)-trans-ML-SI3) is a selective TRPML1, TRPML2, and TRPML3 inhibitor for the study of neurodegenerative and cardiovascular diseases.
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Description(1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 (IC50 values of 1.6 and 2.3 μM) and a weak inhibitor (IC50 12.5 μM) of TRPML3.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2418594-00-8
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Formula Weight429.58
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Molecular FormulaC23H31N3O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (232.79 mM; Ultrasonic )
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SMILESN(S(=O)(=O)C1=CC=CC=C1)[C@H]2[C@@H](CCCC2)N3CCN(CC3)C4=C(OC)C=CC=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Leser C, Keller M, Gerndt S, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021;210:112966. ?
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