γ-Secretase-IN-1( —— )

Catalog No. M34740 CAS No. 209986-17-4

γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

γ-Secretase-IN-1
Note

Research use only, not for human use.
Brief Description

γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.
Description

Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Neuroscience
Target

Gamma-secretase
Recptor

Gamma-secretase | Beta Amyloid
Research Area

——
Indication

——

Chemical Information

CAS Number

209986-17-4
Formula Weight

490.5
Molecular Formula

C27H24F2N4O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (203.87 mM; Ultrasonic )
SMILES

C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J Biol Chem. 2001 Nov 30;276(48):45394-402.?

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