eN-IN-1( 4-Abza | 4Abza | 4 Abza | 4-ABzA | 4ABzA | 4 ABzA | N(6)-(4-aminobenzyl)adenosine )

Catalog No. M16819 CAS No. 95523-13-0

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Datasheet

HNMR

HPLC

MSDS

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Product Name

eN-IN-1
Note

Research use only, not for human use.
Brief Description

An α,β-Methylene-ADP (AOPCP) derivative, potent, selective ecto-5′-Nucleotidase (eN, CD73) inhibitor with Ki of 29 nM for rat recombinant eN.
Description

An α,β-Methylene-ADP (AOPCP) derivative, potent, selective ecto-5′-Nucleotidase (eN, CD73) inhibitor with Ki of 29 nM for rat recombinant eN; also exhibits dual-action properties toward both A2AR and equilibrative nucleoside transporter 1 (ENT1) with Ki of 27.7 uM and 6.51 nM.
In Vitro

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In Vivo

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Synonyms

4-Abza | 4Abza | 4 Abza | 4-ABzA | 4ABzA | 4 ABzA | N(6)-(4-aminobenzyl)adenosine
Pathway

Apoptosis
Target

Adenosine Receptor
Recptor

Adenosine Receptor
Research Area

Neurological Disease
Indication

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1. Bhattarai S, et al. J Med Chem. 2015 Aug 13;58(15):6248-63. 2. Chen JB, et al. ChemMedChem. 2011 Aug 1;6(8):1390-400.

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