Cart
sales@molnova.com
Z-JIB-04
CAS No. 199596-24-2
Z-JIB-04( NSC 693627 )
Catalog No. M13116 CAS No. 199596-24-2
JIB-04 Z-isomer, also known as NSC 693627, is an isomer of JIB-04. JIB-04 is a Jumonji histone demethylase inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 42 | In Stock |
|
| 5MG | 68 | In Stock |
|
| 10MG | 115 | In Stock |
|
| 25MG | 213 | In Stock |
|
| 50MG | 354 | In Stock |
|
| 100MG | 527 | In Stock |
|
| 500MG | 1143 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameZ-JIB-04
-
NoteResearch use only, not for human use.
-
Brief DescriptionJIB-04 Z-isomer, also known as NSC 693627, is an isomer of JIB-04. JIB-04 is a Jumonji histone demethylase inhibitor.
-
DescriptionJIB-04 Z-isomer, also known as NSC 693627, is an isomer of JIB-04. JIB-04 is a Jumonji histone demethylase inhibitor. JIB-04 selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. JIB-04 can prolong survival in a mouse model of breast cancer.
-
In VitroJIB-04 inhibits the demethylase activity of Jumonji enzymes in vitro and in cells, without affecting other α-ketoglutarate dependent hydroxylases or histone modifying enzymes .
-
In Vivo——
-
SynonymsNSC 693627
-
PathwayOthers
-
TargetOther Targets
-
RecptorOthers
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number199596-24-2
-
Formula Weight308.76
-
Molecular FormulaC17H13ClN4
-
Purity>98% (HPLC)
-
SolubilityDMSO: 10 mM
-
SMILESClC1=CN=C(N/N=C(C2=CC=CC=C2)\C3=NC=CC=C3)C=C1
-
Chemical Name(Z)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
HLM006474
HLM006474 is a pan inhibitor of E2F. This inhibits E2F4 DNA-binding (IC50: 29.8 μM in A375 cells).HLM006474 causes the viability of both SCLC and NSCLC lines (IC50 ranging from 15 to 75 μM). HLM006474 displays little activities against E2F4 DNA-binding in A375 cells at 10 and 20 μM, apparently inhibits E2F4 DNA-binding at 40 μM, and increasingly suppresses the effect at 60 and 80 μM concentrations.
-
Algestone acetopheni...
Algestone acetophenide is progesterone that used in estrus synchronization and has been evaluated as an injectable contraceptive in combination with estradiol enanthate.
-
Tiliquinol
Tiliquinol (NSC-130828) (NSC-130828) is a non-absorbed luminal agent with anti-amoebic properties that is often used in conjunction with tibroquinol. It is commonly employed in the study and investigation of amebic liver abscesses.
