Verdiperstat ( AZD-3241 )

Catalog No. M16430 CAS No. 890655-80-8

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Verdiperstat
Note

Research use only, not for human use.
Brief Description

Verdiperstat (AZD-3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO).
Description

Verdiperstat (AZD-3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO); inhibits PMA stimulate neutrophils and zymosan stimulated whole blood with IC50 of 80 nM, efficiently inhibits MPO activity in vivo during acute peritonitis in rats and has consistently shown neuroprotective efficacy in MPTP-lesioned mice, a model of Parkinson’s Disease; also demonstrates significant neuroprotection in MSA mouse model.Spinal Muscular Atrophy (SMA) Phase 2 Discontinued
Synonyms

AZD-3241
Pathway

Others
Target

Other Targets
Recptor

Other Targets
Research Area

Neurological Disease
Indication

Spinal Muscular Atrophy(SMA)

CAS Number

890655-80-8
Formula Weight

253.32
Molecular Formula

C11H15N3O2S
Purity

>98% (HPLC)
Solubility

DMSO : 150 mg/mL 592.14 mM
SMILES

O=C(N1)C(NC=C2)=C2N(CCOC(C)C)C1=S
Chemical Name

1-[2-(propan-2-yloxy)ethyl]-2-sulfanylidene-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

1. Jucaite A, et al. Brain. 2015 Sep;138(Pt 9):2687-700.
2. Kaindlstorfer C, et al. Neurotox Res. 2015 Oct;28(3):185-94.

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