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UR-144
CAS No. 1199943-44-6
UR-144 ( UR 144;UR144 )
Catalog No. M10716 CAS No. 1199943-44-6
A potent, selective full agonist of the peripheral cannabinoid receptor CB2 with Ki of 1.8 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameUR-144
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective full agonist of the peripheral cannabinoid receptor CB2 with Ki of 1.8 nM.
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DescriptionA potent, selective full agonist of the peripheral cannabinoid receptor CB2 with Ki of 1.8 nM, >80-fold selectivity over CB2 (Ki=150 nM); possesses an EC50 of 421 nM for human CB1 receptors, and 72 nM for human CB2 receptors, produces bradycardia and hypothermia in rats at a dose of 10 mg/kg.
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SynonymsUR 144;UR144
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PathwayGPCR/G Protein
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TargetCannabinoid Receptor
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RecptorCannabinoid Receptor
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number1199943-44-6
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Formula Weight311.46
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Molecular FormulaC21H29NO
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCCCn1cc(c2c1cccc2)C(=O)C3C(C3(C)C)(C)C
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Chemical Name(1-Pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Banister SD, et al. ACS Chem Neurosci. 2015 Aug 19;6(8):1445-58.
2. Dhopeshwarkar A, et al. J Pharmacol Exp Ther. 2016 Aug;358(2):342-51.
2. Dhopeshwarkar A, et al. J Pharmacol Exp Ther. 2016 Aug;358(2):342-51.
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